This study was done on 60 blocks from patients diagnosed with invasive breast cancer with known HER2/neu scores. They were divided according to their scores into 4 groups of 15 blocks each. The blocks were submitted for paraffin sectioning followed by staining with immunohistochemical HER2 stain. All the slides were then scanned by the whole slide scanner. Only the group with HER2 score 2+ was tested by FISH.The (score 2+) group when scanned and digitally analyzed revealed three slides to be positive, nine slides to be negative and three slides maintained their equivocal results.The 15 blocks from the equivocal (score 2+) group were further tested by FISH. Two out of the 15 were positive for HER2/neu overexpression, while the remaining 13 turned out to be negative. The two positive cases detected by the FISH were among the three positive cases detected by the quantitative digital analysis.