Asthma is the most common chronic inflammatory disease in childhood and some reports have demonstrated systemic inflammation. The relevance of high sensitivity assays for C-reactive protein (Hs-CRP), which are known to be a sensitive marker of low-grade systemic inflammation, has not been fully studied in childhood asthma. This cross sectional case–control study aimed at evaluating serum Hs-CRP in two groups of asthmatic children, steroid inhaling and steroid naive patients with special emphasis on the relation of measured parameter to different clinical (severity, smoking, family history, other atopic manifestations) and laboratory data (IgE-peripheral blood eosinophil count) and pulmonary function tests. Ninety eight asthmatic Children aged 2yr to 12yr and matched control group of 38 children were recruited for the present study.The Serum Hs-CRP analysis of patients and controls revealed a non significant statistical difference. The relation between the serum analysis of Hs-CRP in the two asthmatic groups was statistically insignificant.A statistical significant difference was found between the HsCRP and the result of the pulmonary function tests, but no statistical significant difference was found between HsCRP and asthma severity. In conclusion HsCRP can be used for indirect detection of airway inflammation, and may be also used to assess response to steroid treatment in asthmatic children but cannot be used as a marker for assessment of different grades of asthma severity.