The aim of the present study was to explore the cellular kinetics, genomic instability and chromosomal abnormalities in Egyptian patients suffering from acute or chronic schistosomiasis haematobium infection.This study was conducted on 46 patients, 22 of them were diagnosed as active cases while 24 patients suffered from chronic schistosomiasis haemotobium complicated by bladder cancer. Three different cytogenetic techniques were employed. These techniques included the nuclear morphocytometric analysis for whole chromosomal content using Feulgen stain, which was performed for all cases. In addition, the Fluorescent In Situ Hybridization (FISH) technique was applied on tissue specimens and the karyotyping technique was applied on peripheral blood monocytes obtained from eight selected cases.All tissue specimens of chronic cases showed positive findings in nuclear morphocytometric analysis in the form of diploidy, tetraploidy and aneuploidy with high poliferative index. As for the ploidy analysis of urine derived epithelial cells from chronic patients, 5 samples showed aneuploid nuclei with high proliferatine index, while in acute cases, epithelial cells were succssefuly recovered and stained in only 4 urine samples, 3 of them were found to be diploid with a high proliferation index.The 8 chronic patients were examined for the specific deletion of the p53 gene locus by FISH. Three samples (37.5%) were found to have a deletion of the p53 gene as evidenced by the presence of a single copy number of the gene. On the other hand, no numerical chromosomal aberrations were detected by karyotyping, where all samples showed a normal male karyotype (46, XY). However, one out of eight cases (12.5%) showed evidence of chromosomal fragmentations.