This study aimed at evaluating the prevalence of degenerative spine disease (DSD) among overweight and obese patients who were referred for bone scintigraphy with or without low back pain. The study included 100 patients who were classified into two groups; group 1 (60 overweight and obese patients with BMI ≥ 25) and group 2 (40 non-obese patients considered as control group with BMI < 25). All patients performed localized MRI on the degenerative lesions seen on bone scan as a standard procedure to confirm the bone scan results. The prevalence of degenerative changes in the current study was 100 % in group 1 Compared to only 40% in non-obese patients. All lesions (mainly lumbar) were confirmed by MRI images.