Preeclampsia is considered one of the main reasons for 34% preventable maternal mortality in Egypt. It is the secondleading cause of maternal mortality after bleeding andhemorrhage. VEGF decreased before the occurrence of preeclampsia byat least 5 weeks of gestation but this decrease did not differentiategestational hypertension from preeclampsia. On the same level as an angiogenic marker, the medianlevel of PIGF was statistically significant when comparing its levelin preeclampsia with controls (P<0.0005).Soluble Endoglin as an anti-angiogenic marker wasincreased in cases of gestational hypertension and preeclampsia.The median level of sEng had a statistically significant difference incomparing gestational hypertension and preeclampsia group withcontrols (P<0.0005).