Obesity is the most common metabolic disease in developed nations. The metabolic syndrome is described as failure of the system of intracellular lipid homeostasis which prevents lipotoxicity in organs of overnourished individuals, a system that normally acts by confining the lipid overload to cells specifically designed to store large quantities of calories , the white adipocytes. Polycystic ovary syndrome is the most common endocrinopathy in women. Metabolic syndrome is evident at an early age in women with PCOS, irrespective of race and ethnicity. The nature of the complex interrelation of hyperandrogenism, the distribution of body fat, and insulin resistance remains unresolved but insulin appears to affect androgen secretion and metabolism, rather than vice versa.Ferritin is an acute phase reactant. A proteolytic product of the transferrin receptor circulates in plasma as soluble transferrin receptor. Samples from females were classified according to BMI into controls, obese and PCOS. Ferritin is significantly elevated in PCOS patients even more than obese, and soluble transferrin receptor is significantly elevated in PCOS patients.