Thalassemia intermedia is a clinical definition in use for a spectrum of clinical conditions ranging in severity fromasymptotic carrier state to the transfusion-dependentthalassemia major. Patients with Thalassemia intermedia arepresented by moderate to severe anemia ( Hb < 10 g / d1 )Splenomegaly , hyperbilirubinemia , a / non a ration higherthen 2.5 ( absolute criteria ) , possibly associated with mild tomoderately elevated HbF level , reticulocytosis , thalassemialike bone modification . Patients require mild therapeuticintervention and occasional blood transfusion may be indicatedlater.Key