We conducted a study to examine to what extent the endothelium cells are injured in glomerulonephritis patients. Forty-five GN patients were dividedin three groups; first was GN with normal kidney function, second GN renalimpairment and third was GN on haemodialysis. vWF and CRP levels weremeasured in all three groups and compared to a healthy control group. Allpatients had biopsy proven GN, non- diabetic and normotesive. Venous sampleswere collected and laboratory investigations were made. vWF and CRP levelswere measured using the ELISA. Our results have proven that endothelial injuryis early in the glomerular disease, even before renal impairment occurs. Resultsfrom the second group have proven that renal impairment further deterioratesthe endothelial cell injury. The hemodialysis group study revealed remarkablefindings. First, CRF independently caused endothelial damage. Second, weconcluded that haemodialysis improves endothelial function inglomerulonephritis patients but, this remains to be proven with a prospectivestudy.