Study of the combinations of all three Markers (CK7, PSA and AMACR) proved that the pattern of having CK7 negativity and both PSA and AMACR positivity is 100% specific for Prostatic carcinoma with a relatively low sensitivity (60%). According to this study also a pattern of CK7 negativity and either PSA or AMACR positivity is 100% specific for Prostatic carcinoma with a higher sensitivity (80%).The pattern of having CK7 positivity and both PSA and AMACR negativity is 100% specific for urothelial carcinoma with a relatively low sensitivity (60%). According to this study also a pattern of CK7 positivity and either PSA or AMACR negativity is 100% specific for urothelial carcinoma with a higher sensitivity (85%).These results proved that a panel of CK7, PSA and AMACR is very useful in differentiating high grade urothelial carcinoma from poorly differentiated prostatic carcinoma