Background: Angiogenesis is a physiological process that humans undergo in order to create blood vessels from pre-existing ones. Angiogenesis is involved in the development and progression of pathogenic processes in a variety of disorders, including inflammatory disorders as psoriasis and rheumatoid arthritis. It has been also been found to be correlated with tumour growth (S-phase fraction) in some lymphoproliferative diseases of B- and T-cell lineages. Objective: The aim of present study is to estimate the level of angiogenin in both plaque Stage Mycosis Fungoides and to compare it to the level in chronic plaque psoriasis. Methods: This study is a cross-sectional comparative study that included 20 patients with psoriasis, 20 patients with mycosis fungoides and 10 age and sex matched healthy controls. Punch skin biopsies were taken from the lesional skin of the psoriatic patients, lesional skin of patients with MF, as well as from the normal skin of the control group and sent for quantitative polymerase chain reaction examination of angiogenin. Results: The angiogenin level in patients with psoriasis was significantly lower than the controls with a median of 0.14, 1.7 µg/mL respectively (p value <0.001), with negative correlation with the age of the patients (p value= 0.012). While in patients with MF, the angiogenin level was significantly higher than the controls with a median of 8.3, 1.7 µg/mL respectively (p value <0.001), with positive correlation with the disease staging. Comparing psoriasis and mycosis fungoides, angiogenin was significantly higher in lesional skin of MF patients than psoriasis patients. Conclusion: Angiogenin expression is elevated in lesional skin of MF with positive correlation with the disease staging and decreased in the lesional psoriatic plaques with negative correlation with the age of the patients. Comparing psoriasis and mycosis fungoides, angiogenin was higher in lesional skin of MF than psoriasis.