Background: Preeclampsia is associated with both maternal andperinatal morbidity and mortality. Histidine-rich glycoprotein (HRG) is aprotein interacting with angiogenesis, coagulation, and inflammatoryresponses, processes known to be altered in preeclamptic pregnancies.Significantly lower levels of HRG have been demonstrated as early as inthe first trimester in women later developing preeclampsia compared withnormal pregnancies.Objective: The aim of this study was to investigate whether thecombination of HRG and uterine artery Doppler ultrasonography can beused as a predictor of preeclampsia.Methods: 70 pregnant female were divided in two groups, thirty five as acontrol group and thirty five as high risk group; they were subjected touterine artery Doppler and measurement of maternal serum HRG in earlysecond trimester at 16 to 18 weeks of gestation, all pregnancies werefollowed until delivery for development of pre-eclampsia.Results: In the cases that developed preeclampsia in comparing with uneffectedpregnancies it was noticed that they had low serum level of(HRG) and higher (PI and RI) which were statistically significantdifference.Conclusion: Use of uterine artery Doppler indices,in combination withmeasurement of serum level of HRG is valuable as early second trimesterpredictor of preeclampsia.