Cadmium (Cd) has been recognized as one of the most toxic environmental pollutants. The major sources of Cd intake are foods of plant origin, sea food and tobacco. Supplementation of antioxidant is one of the important components of an effective treatment of Cd poisoning. The administration of ascorbic acid or selenium have protective effect on Cd-induced oxidative stress .The present study used 70 adult male albino rats; their weight ranged 200-250g. They were divided into seven groups. Cadmium was found to cause injury to the rat gastric mucosa which was obviously protected when ascorbic acid or selenium was given.