Objective: Patients with chronic renal failure (CRF) under hemodialysis therapy experience a significant decrease in quality of life, due both to the limitations imposed by the disease as well as the demands of the treatment that they receive. The aim of this study was to determine the prevalence of erectile dysfunction and associated risk factors in patients with renal disease under hemodialysis therapy. Methods: A cross-sectional study was conducted to determine the prevalence of ED among a community-based hemodialysis (HD) population. The presence and severity of ED were assessed among 134 End stage renal failure patients on hemodialysis therapy using the self-administered International Index of Erectile Function-5 (IIEF-5) questionaire as well as a questionnaire scanning for other risk factors of erectile dysfunction.Results: The prevalence of any level of ED was 95.5% for all HD subjects. Data were used to examine and test associations between ED and associated medical conditions. Analysis showed that age, hypertension and anti hypertensive medications have a significant association with the presence of ED among HD patients (p<0.05).Conclusions: Erectile dysfunction is extremely prevalent among HD patients. A complete health evaluation of male HD patients should include a discussion about their erectile function in the standard clinical care program of patients with renal disease.