Renal injury accounts for 10-18% of causes of early mortality after aortic aneurysm surgery. Patient after having undergone aortic aneurysm surgery may go into renal failure in 8.5-33% of cases. Seeing the grave consequences of aortic aneurysm with renal involvement it needs very precise management of such patients. Propofol and volatile anesthetics have been reported to modulate ischemia reperfusion (I/R) injury suggesting their potential for organ protection during surgery involving abdominal aortic clamping and possibly a means for improving patient outcome. Propofol is a lipophilic hypnotic drug with proven antioxidant activity in both in vitro and in vivo studies resulting in part from its chemical structure, which is similar to the natural antioxidant vitamin E. Sevoflurane suggested suppressing pro-inflammatory effects of tumor necrosis factor ntf and reduced necrotic cell death induced with HO in human kidney cells and hence has direct anti-inflammatory and anti-necrotic effects in vitro. following I/R injury. Nuclear transcription factor kappa beta (NF B) is a pivotal transcription factor that plays a key role in oxidative stress and inflammatory responses activated during IR.Activation of (NFB) induces expression of a variety of gene products, including cytokines and pro-inflammatory enzymes (TNF- & IL1that lead to I /R injury. Measuring TNF- and IL1- with resulting renal function serum creatinine could justify the superiority of either propofol or sevoflurane on renal protection as part of clear future strategy in anesthetic management of suprarenal infracoeliac aortic surgery