Background: Recent studies revealed that multiple sclerosis (MS) patients have increased risk of developing cardiovascular events like stroke and myocardial infarction than their age matched population. Arterial stiffness and carotid intima media thickness both are powerful, independent predictors of cardiovascular diseases and subclinical atherosclerosis. Aim of the study: was to assess small and large arterial stiffness and carotid artery intima media thickness in multiple sclerosis patients. Subjects and methods:the study was conducted on 55 subjects 33 MS patients and 22 healthy control subjects, the patients ages ranged from 23 to 35 years and the control group’s ages ranged from 25 to 35 years. All subjects were subjected to intima media thickness (IMT), brachial ankle (baPWV) and brachial femoral pulse wave velocity (bfPWV) measurements, in addition to expanded disability status scale only to MS patients. Results: baPWV was significantly higher in MS patients compared to the healthy controls (p =0.014), secondary progressive multiple sclerosis (SPMS) patients had significantly higher bfPWV and IMT compared to the relapsing remitting multiple sclerosis (RRMS) patients. (p=0.033 and P=0.022 respectively), baPWV, bfPWVand IMT were significantly higher in the male patients compared to the female patients. (p <0.001,p=0.006and P=0.005 respectively). Conclusion: Multiple sclerosis may be considered an independent risk factor for small and large arterial stiffness in young patients with the disease.