Our aim was to confirm safety and demonstrateefficacy of introduction of lipids through parenteral nutrition in pretermand term neonates regarding the weight gain, sepsis and othercomplications including (intraventricular hemorrhage, cholestasis,metabolic disturbences, and bronchopulmonary dysplasia). Case-control study comparing weight gain and differentcomplications in 80 patients were performed, 35 patients receivedparenteral nutrition without intralipids and 45 patients received parenteralnutrition with intralipids. The daily weight gain, investigations includingCBC, CRP, blood culture, glucose level, electrolytes (Na, K, Ca), liver and kidney functions and lipid profile were obtained. We evaluated weight gain, sepsis, intraventricularhemorrhage, cholestasis, bronchopulmonary dysplasia and metabolicdisturbences in 80 neonates. Of the 80 samples, 35 (43.75 %) casesreceived parenteral nutrition without intralipids, and 45 (56.25 %) casesreceived parenteral nutrition with intralipids. There was a statisticallysignificant positive (direct) correlation between receiving total parenteralnutrition with intralipids and weight gain. Receiving Total parenteral nutrition with intralipidsin neonates was associated with better weight gain and doesn’t increaserisk of sepsis or other complications compared to receiving parenteralnutrition without lipids.