The aims of work were to determine the prevalence of childhood asthma, associated risk factors, and to assess the quality of life of the children and caregivers. The sample was randomly chosen from Nasr-City in Cairo governorate. 1461 families participated with 2394 school age children. 250 children were asthmatic with prevalence of 10.4%. Statistically significant relations were detected between the quality of life and each of maternal age, maternal education, maternal occupation, crowding index, house ventilation, Hospital admission for asthma, and Medical information by medical team about asthma.