Objective: The present study was performed to compare sexual, marital and psychological aspects of infertile males and infertile females. Method: After obtaining their consents, 50 infertile males and 50 infertile females answered 3 questionnaires of symptoms checklist 90, index of marital satisfaction (IMS) questionnaire & sexual satisfaction scale (SSS) questionnaire. Results: The study showed that infertile females tend to have higher levels of depression, anxiety, somatization and interpersonal sensitivity as compared to infertile males. Age, infertility duration and most of psychiatric disorders of subjects have no effect on marital or sexual satisfaction. Marital and sexual satisfactions are affected by each other positively in both genders. Conclusion: Infertility diagnosis is an important factor in assessing the differences in infertility distress, marital satisfaction and sexual satisfaction particularly for women. Adequate attention to these patients psychologically is of such importance as physical attention.