Pediatric uveitis is relatively uncommon, but comprises a serious group of diseases that can lead to significant ocular morbidity and vision loss.The diagnosis and management of chronic pediatric uveitis is a challenge to the ophthalmologist, and needs the integration of data obtained from history, clinical examination and ancillary laboratory and ophthalmic investigations.The ophthalmic investigation modalities : ultrasonography, UBM, fluorescein and ICG angiography, laser flare photometry and OCT have a role in the diagnosis and follow up of the disease. Tissue and ocular fluid specimens are sometimes necessary. These tissue samples undergo cytological and microbiologic examination as well as molecular techniques e.g PCR for detection of infectious or neoplastic etiology.The treatment of chronic pediatric uveitis was initially dependent on corticosteroids, both topically and systemically. However, the side effects of long term steroid therapy in children, especially concerning growth, led to the emergence of other (steroid-sparing) immunosuppressive therapies and the newer biological modifier drugs that addresses specific components of the immune system. Surgical treatment is required in many cases of pediatric uveitis with complicatios which can not be managed with medical treatment, the commonest being cataracts, glaucoma, band keratopathy and vitreoretinal complications. Specific preoperative, operative and postoperative precautions are required in these cases to minimize complications and improve the outcome.