Background: Cardiac complications are relatively common in β thalassemia. Pulmonary hypertension (PHT) is a common yet poorly understood complication of β thalassemia. The etiology of PHT in thalassemia is multifactorial. Objectives: We aimed to detect the presence of PHT, to assess cardiac dimensions and functions and to study the relationship between PHT and various clinical and laboratory characteristics among thalassemia intermedia (TI) patients. Method: This is a prospective observational study included sixty patients with TI, ages 6-28 years (13.5±6.6 yrs) and including 24 (40 %) males and 36 (60%) females. Retrieved data included demographics and clinical characteristics. Laboratory parameters and therapeutics that may influence PHT development were collected. Trans-thoracic (2D) guided, (M mode) and Doppler echocardiography were performed for all patients. Result: The overall prevalence of PHT was 53.3%. The duration of follow-up, splenectomy, serum ferritin & platelet count were significantly higher among cases with PHT. Mean TRV, TRPG, PRV, PRPG, PV, PPG, MPI (RV) and IVS were significantly higher in PHT positive group (P ≤ 0.05). Mean PAP was significantly correlated with the duration of follow-up, reticulocytic count, total bilirubin, serum ferritin, LVEDD, IVS, LVM, LVMc, MPI (RV) and IRT (P ≤ 0.05). Conclusion: The prevalence of PHT among our TI patients was 53.3%. Long duration of disease, splenectomy, high serum ferritin, high platelet count and increased hemolytic rate were found to be risk factors for development of PHT.