This study was carried out among pupils of first and second preparatory grades one private preparatory school for boys and another one for girls and first secondary grade of one secondary nursing school for a sample of 248 pupils to test the feasibility of the implementation of a school based program for prevention of drug use “Unplugged” in Egypt which is implemented effectively in schools of some European countries. The intervention arm received parts of the unplugged program while the control arm received no intervention. Pre and post intervention assessment were done using an assisted questionnaire form to obtain data about own substance use, knowledge and opinion about substances, substance use in the close environment, family and social environment, school environment and climate and problem and skills. In addition, the pupils and conductors’ comments and evaluation of the lessons were obtained through in depth interview with the conductors, pupils’ comment forms and lessons’ monitoring forms. Analysis of the quantitative study data which was obtained from the questionnaire was based on comparison of the intervention to the control group in each school separately as well as comparison of the pretest to the posttest for the different groups while the qualitative study components obtained from the monitoring and evaluation forms was analyzed using Talley charts which were used to summarize and categorize the responses of pupils supported by quotations of the pupils’ in their own words and a report was prepared from the lesson monitoring form and the conductors’ interview. The study results showed improvement of the beliefs on consequences of cigarettes use among boys’ intervention group. Benefiting from these abridged lessons was the common theme in the pupils’ comments with a great desire among pupils and conductors to learn more, which provides evidence for the potential success of the program when fully implemented.