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Risk factors of interferon retinopathy in hepatitis C virus patients

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Opthalmology

Advisors

Sheta, Sherif M. , Sawabi, Emad A. , Abdel-Qader, Ahmad A.

Authors

Fadhel, Maryam Raouf

Accessioned

2017-07-12 06:40:36

Available

2017-07-12 06:40:36

type

M.Sc. Thesis

Abstract

Objective: Chronic Hepatitis C is common problem worldwide treated by combination of interferon alpha and ribavirin. Retinopathy is one of the side effects of interferon therapy. The aim of this study is to determine the frequency and risk factors of retinopathy in patients with chronic hepatitis C treated by interferon and ribavirin combination therapy in Egypt. Study Design: Prospective observational descriptive study. Place and Duration: This study was conducted in the department of ophthalmology, Kasr AlAiny Hospital, Cairo University; from July 2011 to May 2012. Patients And Methods: All chronic hepatitis C patients (50 patients) which were selected from Kasr AlAiny Viral Hepatitis Center. Patients aged from 20 to 60 years with positive HCV RNA by Polymerase Chain Reaction were included. Past medical history of hypertension and diabetes were taken. Full ocular examination was performed before start of treatment andat 3 months and 6 months interval. Main Outcome Parameter: The risk factors of interferon retinopathy in hepatitis C virus patients. Secondary Outcome Parameter: Ocular interferon related complications other than retinopathy in hepatitis C virus patients. Results: Total 50 patients were enrolled among which, 8 (16%) developed retinopathy in the form of cotton wool spots and 7(14%) developed atypical complications. Patients who developed retinopathy were subdivided into patients with no co-morbid illness (6%); diabetics (6%); patient with systemic vasculitis (2%) and with low hemoglobin level (2%). Conclusion: Retinopathy may occur in patients with chronic hepatitis C receiving interferon alpha and ribavirin, commonly in patients with diabetes.

Issued

1 Jan 2012

DOI

http://dx.doi.org/10.21473/iknito-space/35643

Details

Type

Thesis

Created At

28 Jan 2023