Congenital anomaly consists of a departure from normal anatomical architecture of organ or system. The prevalence of congenital anomalies detected at birth is about 2.5 % while long-term follow up studies increase the incidence to 14-15%. Congenital anomalies are the leading causes of infant mortality and one of the leading causes of long term morbidity. Causative factors of congenital malformations are divided into four major groups: single gene mutation, chromosomal abnormalities, multifactorial conditions and environmental factors. Birth defects can arise in at least three ways. The most common type of structural fetal abnormality is a malformation, an intrinsic abnormality "programmed" in development from the third to eight weeks, regardless of whether a precise genetic etiology is known. An example is spina bifida.