IBD and FMF share common clinical and biological features. This study aimed atdetermining the prevalence of MEFV gene mutation in IBD patients and tocharacterize FMF-IBD patients. It enrolled 17 patients with UC, 15 with CD, 10with IC and 33 controls. All cases were screened for 12 MEFV gene mutations.88.1% of the IBD patients carried the mutation versus 42.4% control cases. Datawere comparable between MEFV positive and negative IBD patients. IBD patientsliving in countries where FMF is frequent should be screened for FMF.