Aim of Work: Analysis of colorectal polyps cases in 5 years duration, to detectrate of occurrence of different types. Statistical evaluation of all available data inthe request sheets and the pathological findings of cases is done.Methods: Slides and data were obtained from archives of pathology department,Faculty of Medicine, Cairo University, Kasr El Aini Hospitals (2006-2010).Results: 225 colorectal polyps cases were studied, 168 are non-neoplastic polypsand 57 are neoplastic polyps. The mean age of patients with nonneoplasticpolyps is 36.6 years; while that of patients with neoplastic polyps is 51.2 years.The male predominance is clear in the results of this study as the male to femaleratio in nonneoplastic polyps is 1.8:1 and of the neoplastic polyps is 2:1. Thepresenting symptom in this study is bleeding per rectum, being the mainsymptom in 67.2% of cases. The rectal region is the most common segmentinvolved, 49.7% of polyps are found in the rectum. Most of the nonneoplasticpolyps are pedunculated (51%) while the majority of neoplastic polyps aresessile (77.8%). The tubular adenoma is the most common type representing47% of the adenomatous polyps. Most adenomas are of low grade dysplasia.Mixed hyperplastic adenomatous polyps represent 8.4% of colorectal polyps,while serrated adenomas represent 1.8% of colorectal polyps. Hyperplastic polpsare the most common type in non neoplastic polyps (44%), followed byhamartomatous polyps (35%).Recommendations: Understanding the natural occurrence and the features ofcolorectal polyps is crucial in any CRC prevention strategy. A CRC screeningprogram represents an urgent need nowadays.