The supracricoid partial laryngectomy (SCPL) was developed in the late 1950s as an alternative to total laryngectomy (TL). SCPL has the advantages of preservation of speech and swallowing function without a permanent stoma and a very high local control rate for selected glottic and supraglottic cancers. While in total laryngectomy esophageal speech is used as an alternative method of communication and many protocols were previously used to evaluate it, the phonatory ability of the residual larynx after SCL has to be completely re-estimated, due to the altered anatomo-physiology of the structure after surgery, in fact, the residual larynx determines a definitely reduced periodic acoustic signal, rich in noise. Good phonatory results of this treatment are basically due to preservation of intelligible speech which, by ensuring the subjects’ speech ability, overcomes and has little influence on the disturbed quality of the vocal signal in these patients. However, the patient obtains a “new voice” as far as concerns acoustic features and this is very important for communication and social life, hence it was important to investigate the Voice Handicap Index (VHI), the health-related quality of life (HRQL), and the correlations between VHI and HRQL in laryngectomees. In fact, after SCPL, the anatomic, functional and acoustic situation is totally different from those in “common dysphonia” and conventional phono-surgery results so it was inevitable to create a new assessment for substitution voices, which is the INFVo protocol that assesses the intelligibility, the noise, the fluency and the voicing on the substitution voices.