Portal hypertension is characterized by a pathological increase in portal pressure, and often leads to the formation of esophageal varices and ascites. Bleeding esophageal varices were found to be responsible for more than half of cases presenting by upper gastrointestinal hemorrhage. The potent vasoconstrictive peptide, Endothelin-1 (ET-1) is increased in liver cirrhosis suggesting a possible role for this vasoactive peptide in the pathogenesis of portal hypertension. This study was designated to determine circulating and hepatic tissue ET-1 in Egyptian patients with and without bleeding esophageal varices dou to liver Cirrhosis. Plasma and hepatic tissue endothelin-1 were detected in our study by ELISA technique in Seventy-five individuals. Our result shows a significant increase of plasma and hepatic tissue Endothelin-1 in bleeding esophageal varices duo to liver cirrhosis.