Both increased Knowledge of the importance of cytokines in the studies have examined the relationship between the cytokines and renal allograft rejection. Thus, it is important to identify those cytokines which are involved in allograft rejection in order to develop therapies and allograft rejection. From our study, we completely cells, IL-10 can inhibit TH1 cytokine synthesis. It may be of value in treatment of inflammatory diseases, IL-10 is attractive candidate in treating a variety of T cell mediated autoimmune diseases such as type I diabetes and multiple sclerosis, IL-10 has been found in the supernatant of several human cancer cell lines as ovarian drugs and the occurrence of true rejection. Future studies are cancers.IL-10 plays a critical role in the emergence. In this study, we aim at studying the effect of this cytokine on renal allograft outcome. We measured serum and urinary levels of IL-10 in renal transplant patients more than one year with and without renal rejection.