Background: Psoriasis is a common chronic immune-mediated skin disease. Its prevalence is estimated to be anywhere from 0.6 to 4.8%. Hepatitis C is a serious public health problem all over the world with a global prevalence of 3%; Egypt has the highest HCV prevalence in the world. Studies have reported high prevalence of hepatitis C infection (HCV) among patients with psoriasis. Objectives: To estimate the prevalence of HCV infection among psoriatic patients and to define the underlying risk factors for the occurrence of HCV infection among psoriatic patients. Patients and methods: One hundred psoriatic patients recruited from the Dermatology Outpatient Clinic, Kasr Al-Aini, Faculty of Medicine. And 200 healthy volunteers collected from blood bank of Kasr Al-Aini hospital as blood donors. Estimation of liver functions, anti HCV antibody (HCV-Ab) was done to all patients and control. Qualitative HCV RNA by PCR analysis was performed for those who were HCV-Ab positive. Results: The prevalence of HCV infection was significantly higher in psoriatic patients when compared to control group (p < 0.05). Also the severity of psoriasis was statistically significantly higher among HCV +ve Psoriatic patients compared to HCV -ve Psoriatic patients (p < 0.05). Liver enzymes level was statistically significantly higher among psoriatic patients when compared to controls; among HCV +ve psoriatic patients when compared to HCV -ve Psoriatic patients and among HCV +ve psoriatic patients when compared to HCV +ve control subjects (p < 0.05). PCR analysis proved that the most prevalent genotype of HCV among both psoriatic patients and control subjects was Genotype IV while only two cases of concomitant HCV infection and psoriasis were Genotype II. Conclusions: Our observation supports previous reports of an association between psoriasis and Hepatitis C. Patients with concomitant HCV infection and psoriasis tend to have more severe form of psoriasis; which necessitates longer duration of treatment and more aggressive form of HCV infection with more liver damage. Physicians who care for patients with psoriasis should be aware of this possible association and consider screening patients with psoriasis for Hepatitis C.