Background: Skin warts (verrucae vulgaris) are benign proliferative lesions of the epidermal cells. Angiogenesis and vasodilatation are said to be associated with the development of common skin warts in previous reports. In a previous trial to investigate the possible cause of angiogenesis in skin warts, VEGF expression was found to be not associated with angiogenesis or vasodilatation in skin warts. Angiopoietins, as angiogenesis factors, have not been studied before in warts.Aim of the work: This study was conducted for assessment of the level of Ang1, Ang 2 and Tie2 in common warts and to verify their possible role as angiogenisis factors Subjects and methods: The study included 50 patients with common skin warts and 50 healthy controls who are age and sex matched, a-4-mm punch skin biopsy was taken from the lesional skin of patients and normal skin of the healthy controls for detection of gene expression of Angiopioetin1, Angiopioetin2 & Tie2 using real time PCR technique.Results: The mean value of Ang1, Ang2 and Tie2 was statistically higher in the lesional skin (wart) of the patients than in the normal control skin and this difference was statistically significant (P value <0.001 for all). Correlating levels of Ang1, Ang2 and Tie2 in the tissue of verruca patients of the studied cases to their age, duration of illness, number of warts revealed no statistically significant relation.Conclusion and Recommendations: Upregulation of Ang1, Ang2 and Tie2 could have a role in the angiogenesis associated with common skin warts. Further studies are needed to verify the possible role of other angiogenic factors in warts as well as the possible role of Ang1, Ang2 and Tie2 in other types of warts.