Background: The baroreceptor reflex is the main mechanism for short-term regulation of blood pressure and a major determinant of the blood pressure responses associated with various behaviors. Baroreflex sensitivity (BRS) is the amount of change in beat-to-beat interval (RR) against a 1mm Hg systolic blood pressure deviation. BRS is traditionally measured by bolus injection of vasoactive drugs such as phenylephrine which causes increase in systolic blood pressure (SBP) or Na nitroprusside (NTP) which causes decrease in systolic blood pressure. Methods: This comparative study included 60 patients who were scheduled for laparoscopic gynecological surgery. Patients were divided into three groups (Propofol-group), (Sevo-group) and (combined Propofol and Sevo group) with 20 patient in each group. Pressor and depressor tests were done pre, intra and postoperative with recording systolic blood pressure and R-R interval as well as the diastolic overshoot in the awake state, under anesthesia and postoperatively.Results: There were no significant differences in patient population demographic data, awake pretest SBP and HR. The results of our study suggest that there was no significant depression of baroreceptors except for the depressor slopes in the propofol group after induction of anesthesia with full recovery of baroreceptors in the postoperative results.Also, Our study stated that blood pressure was significantly lower among patients confined to sevoflurane group as compared to other two groups suggesting that haemodynamics were more affected when using sevoflurane alone than using propofol alone or in the combined group.Conclusion: Data obtained from this study showed that use of propofol alone may lead to depression of baroreceptors as compared to sevoflurane alone or combined use of them. On the other hand, haemodynamics were affected when using sevoflurane alone than using propofol or combined use of them.