There is a close association between ischemic cardiovascular disease and hypercholesterolemia. The present study was aimed to evaluate the effect of induced hypercholesterolemia on the testis and epididymis of adult albino rats and to elucidate the possible protective role of atorvastatin and selenium. Fifty adult albino Wistar rats were divided into five groups; control group, sham control, induced hypercholesterolemia group, induced hypercholesterolemia treated with atorvastatin group and induced hypercholesterolemia treated with selenium. The effects were monitored histologicaly, ultrastructurally, Biochemically and morphometrically. Induced hypercholesterolemia produced marked histological and ultrastructural changes in the testis. Morphometrically, there was a significant decrease (p<0.0001) in the diameter of the seminiferous tubules, significant increase (p<0.0001) in the collagen fibers in the testes of rats and significant reduction (p<0.0001) in the polysaccharides content of induced hypercholesterolemia group rats as compared to the control groups. Atorvastatin and selenium produced marked improvement in histological and ultrastructural results as compared with group induced hypercholesterolemia. However, some ultrastructural changes were evident in the selenium treated group. Morphometrically, Atorvastatin and selenium produced significant increase of the diameter of the seminiferous tubules, significant increase in the area percent of collagen fibers, significant increase in the polysaccharides content as compared to induced hypercholesterolemia group. Hypercholesterolemia also produced many histological and ultrastructural changes epididymis. Morphometrically, the area percent of collagen fibers in induced hypercholesterolemia group was significantly increased (p<0.0001) as compared to control groups. Atorvastatin and selenium improved the histological and ultrastructural changes in the epididymis as compared to induced hypercholesterolemia group. Morphometrically, atorvastatin and selenium significantly decreased (p<0.0001) the area percent of collagen fibers as compared to group III. However, the present study didn't reveal any significant change in the optical density of PAS reaction of the epididymis among the five groups. Feeding rats with high cholesterol diet induced significant elevation (p<0.0001) of the serum level of cholesterol, TG and LDL as well as significant decrease in the serum level of HDL compared with control rats. Atorvastatin and selenium produced significant (p<0.0001) improvement in the in the serum level of LDL, HDL and triglycerides. Conclusion; it could be conclude that induced hypercholesterolemia produced injurious effects to both testis and epididymis and both atorvastatin and selenium could ameliorate these deleterious effects.