Obesity is a multifactorial disease with genetic and environmental origins, resulting from imbalance between energy intake and expenditure. Our study aimed at studying the association between FoxO genes (1a and 3a) polymorphisms and obesity, we found that polymorphism existed only in obese patients although the controls showed no polymorphisms in either FoxO genes (1a and 3a). Also, we found a statistically significant positive correlation between increase fasting insulin, insulin resistance and FoxO 1a polymorphism. Increase fasting insulin and increase insulin resistance will lead to obesity. So, this correlation indicates that if the individual has FoxO 1a gene polymorphism, he will have strong chance to be obese. This patient must follow all the strategies for obesity prevention and management including physical activity, diet control and behavioral changes. Moreover, this patient has also strong chance to be type 2 diabetic patients. So, diet control and physical activity are a must. The results of this study lead us to take into consideration the following recommendations ; Children having family history of obesity will benefit from gene therapy so that dealing with FoxO 1a polymorphism may prevent obesity.