The term adhesion molecules refer to those cell surfacestructures that allow cells to adhere to other cells or to extracellular matrix molecules. Adhesion processes are required forcells to interact and to migrate to their place of destination. The adhesion molecules: intercellular adhesion moleculesICAM-1(CD54) and vascular cell adhesion molecules VCAM-1(CD106) play a role in the altered adhesion, invasiveness andmetastasis properties of blast cells. We estimated the level of ICAM-1 and VCAM-1 in 31 cases of denovo adult acute leukemia cases comparing it with 30 healthy control using flow cytometry. We found that the level of ICAM-1 and VCAM-1 was higher in adult acute leukemia cases compared with 30 healthy controls these levels were correlated with number of blast cells in peripheral blood. And thus it may affect prognosis and it may define a modifiedregimen for treatment.