Background: Palmoplantar psoriasis is a distressing and disfiguring disease, often resistant to treatment. Topical and systemic treatments are not always adequately effective and their use may be limited by side effects. Therefore, clinicians have sought alternative methods and have turned to lasers for treating psoriasis.Objective: To compare 2 types of lasers in treating palmoplantar psoriasis, the pulsed dye laser (595 nm) and the combined pulsed dye (595 nm) and Nd: YAG (1064 nm) laser.Methods: Twenty patients with palmoplantar psoriasis were included. Ten of them were treated with PDL on the left palm or sole and the combined (PDL and Nd: YAG) laser on the right palm or sole. Before the sessions they used salicylic acid 10% ointment for 2 weeks and in between only Vaseline. 4 laser sessions were done at 2 weeks interval and then they were followed for 1 month. The other ten patients were considered as control, applying 10% salicylic for 2 weeks then Vaseline for 3 months.Results: A statistically significant difference was seen favoring the combined laser when comparing it with the PDL on the palms, P value=0.043. Both lasers showed comparable results on the soles, P value=0.655. The combined laser showed statistically significant difference when compared with the control group on the palms, P value=0.005 and on the soles, P value=0.01. The PDL showed statistically significant difference when compared with the control group on the soles, P value=0.02, but not on the palms, P value=0.113. 1 month follow up still showed some improvement on the palms, but some degree of recurrence was seen on both soles. Conclusion: Both PDL and combined PDL and Nd: YAG can be used in treating psoriasis, however better results could be obtained by combining laser with other modes of therapy.