Following acute myocardial infarction (MI) rennin angiotensine system (RAS) plays an important pathophysiological role in inducing left ventricular (LV) remodelling providing a rational for the use of angiotensine converting enzyme (ACE) inhibitor following acute (MI).There has been a recent interest in the role played by angiotensine receptors in modifying post MI remodelling, and the question arises could angiotensine II receptor (ATII) blocker be as beneficial or more beneficial than ACE inhibitor in modifying cardiac remodelling?Studying the effect of angiotensin II receptor antagonist treatment on left ventricular function in patients with acute myocardial infarction in comparison to ACE inhibitor revealed that advantages inherent in using ATII receptor blockers following acute MI. Beneficial effect on systolic and diastolic function were comparable to those obtained by standard ACE inhibitor therapy as the beneficial effect of early use of oral ACEI after MI was already confirmed , ARBs could be prescribed when ACEI not indicated.Conclusion: The beneficial effect of early use of oral ACEI after MI was already confirmed. Our data point to the advantages inherent in using angiotensin II receptor blockers following acute MI. Beneficial effects on LV dimensions, systolic and diastolic functions are comparable to those obtained by the standard ACE inhibitor therapy although, more effective in reducing LV systolic and diastolic measurements post myocardial infarction.