This work aimed to study the effect of different clinical male parameters on ICSI outcome in a retrospective study of 488 infertile couples who underwent 525 ICSI cycles, performed for treatment of male factor infertility, from July 2001 through February 2003. Female factor was excluded, the ICSI procedure used for all patients were done in one place, and by the same technique and operators. The fertilization, implantation, pregnancy, and abortion rates were measured in relation to different clinical male parameters. There were significant high fertilization rates in patients with ejaculate spermatozoa, patients with sperm count > 5X106 /ml, patients with abnormal sperm forms <95% and in patients where testicular spermatozoa retrieved easily. There were significant low fertilization rates in smoking patients, patients with abnormal testicular histopathology, and patients with leucocytospermia. No significant differences were detected in implantation, pregnancy and abortion rates for patients with different clinical male parameters. In conclusion, the implantation, pregnancy and abortion rates of ICSI, were not influenced by any clinical male factor.