Juvenile rheumatoid arthritis is one of the most common chronic rheumatic disorders of childhood. Markers of inflammation play a major role in detecting disease activity and response to treatment; measurement of acute phase response is widely used as an indicator of disease activity. The aim of our study was to detect presence of amyloid A protein in serum and synovial fluid and to correlate it with clinico lab. parameters and to correlate it with C-reactive protein. Study included 40 patients divided into 2 groups according to presence or absence of disease activity. A high statistical significance was detected between both groups regarding serum and synovial amyloid A protein and statistical significance was detected between serum amyloid A and C-reactive protein. This indicates that acute phase proteins could be considered as inflammatory mediator in JRA disease and could play a role in its pathogenesis.