Mycosis fungoides is a major subset of CTCL that evolves through patch, plaque and tumor stages before lymph node and visceral involvement occurs. The study used several methods of treating MF deals with the whole skin, clinically involved and normally appearing, though little is known about the microscopic appearance of clinically uninvolved skin. The aim of our study was to evaluate the degree of histopathological involvement of normally looking skin in MF patients. Thirty patients with stages (Ia,Ib,IIa,IIb) were biopsied from normal skin. Two biopsies were taken, one proximal (2 cm) and the other is distal (> 5cm) from any visible lesion. 10 normal controls were included in the study. Epidermotropism was detected is 21 (70%) of proximal skin biopsies and 14 (47%) of distal skin biopsies and no biopsy from the control group showed epidermotropism and these differences were statistically significant. All proximal skin biopsies showed dermal infiltrate and 90% of the biopsies from distal normal skin showed dermal infiltrate mostly superficial perivascular and these findings were also statistically significant. In conclusion: normal skin in MF patients could be affected microscopically and this may affect the prognosis of the disease.