Birth asphyxia is a major cause of neonatal mortality and morbidity. Asphyxia greatly affects the coagulation system of the affected neonates. We measured protein c, protein s and antithrombin III levels in ten asphyxiated neonates and ten non asphyxiated neonates served as control group. The study revealed the effect of decreased levels of the physiologic inhibition system of coagulation (PISC) including protein c, protein s and antithrombin III on further development of thromboembolic complications in asphyxiated neonates, as 50% of the studied cases developed disseminated intravascular coagulation (DIC).