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Feasibility of US-guided radiofrequency ablation in treatment of early breast cancer

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Radiodiagnosis

Advisors

Hamed, Suha T. , Shaaban, Muhammad H.

Authors

El-Ghubashi, Muhammad Hamadna-Allah

Accessioned

2017-04-26 12:37:46

Available

2017-04-26 12:37:46

type

M.Sc. Thesis

Abstract

Since the use of radical mastectomy, new treatments have been developed to reduce the amount of tissue removed during surgery resulting in a better cosmetic outcome. The surgical treatment for small breast cancer nowadays is mostly lumpectomy followed by radiotherapy. This procedure is combined with sentinel lymph node mapping which decreases the number of unnecessary axillary lymph node dissections. Randomized studies have documented similar survival rates between patients undergoing radical or modified radical mastectomy and breast conserving therapy .As the management of breast cancer evolves towards less invasive treatments, several techniques have been developed to improve local eradication of breast tumours. One of the most promising of the non-invasive ablation techniques is radiofrequency ablation (RFA). RFA is produced by frictional heating. Electrode tips placed in the lesion produce a high-frequent current that flows into the surrounding tissue initiating ionic agitation that causes heat and, in the end, cell destruction. RF ablation is a promising minimally invasive treatment of small breast carcinomas, as it can achieve effective cell killing with a low complication rate. Further research is necessary to optimize this image-guided technique and evaluate its future role as the sole local therapy. However, non-surgical ablation techniques still have a number of problems with regard to determination of 100% tumor cell killing and assessment of tumor margins and ability to follow local recurrence. To achieve wide acceptance, non-surgical ablation techniques must achieve results equivalent to those of conventional breast conserving treatment (BCT) in local control and survival.

Issued

1 Jan 2009

DOI

http://dx.doi.org/10.21473/iknito-space/33432

Details

Type

Thesis

Created At

28 Jan 2023