The diagnosis of IBD is a challenging; as it constitutes a variety of examination techniques that must be performed. Cross-sectional imaging, as CT and MRI, has important roles in the evaluation of IBD patients. Double-contrast barium studies are valuable techniques in diagnosis of Crohn’s disease and ulcerative colitis in patients with early disease; whereas cross-sectional imaging are valuable for showing the effects of this disease on the wall of the bowel and diagnosis of their intra-abdominal complications in patients with more advanced disease. The conclusion is that MSCT is a reliable, advanced and non-invasive technique for diagnosis and evaluation of different causes of IBD; but it can’t detect the early changes of the disease. So, MSCT is essential in assessment of extra-luminal extension, abscesses, fistulas and other complications of IBD; whereas barium studies and endoscopy have limited values.