Objectives: Supracricoid laryngectomy is largely affected by invasion of the tumor into the paraglottic space. Histopathologically examine if supracricoid laryngectomy gives adequate safety margins regarding the paraglottic space or not. Methods: A prospective study on 20 patients with advanced cancer larynx staged as T2b, T3 and cases with failed radiotherapy where supracricoid laryngectomy was done with whole organ transverse sections of the specimens to evaluate the relation of the tumor to the paraglottic space. Results: Local success rate in this study was 90%, one case showed infiltrated surgical margins and the other showed local recurrence six months after the operation. Conclusions: Supracricoid laryngectomy allows for safe enbloc resection of malignant tumor in the larynx with complete resection of the whole paraglottic space. At least 4 mm safety margin is needed to eradicate the tumor as revealed by the whole organ section technique.