The current study compared between 2D US and 3D US in evaluation of fetal anomalies. Eighty one women with 84 fetuseswere examined by 2D followed by 3D US, and 105 detectedanomalies. Our results demonstrate an advantage of 3D US over2DUS in 8.6% of cases, equal findings in 71.4%, and less informationin 20% of anomalies detected.According to our findings, 3D/4D US has shown advantage over2DUS in demonstrating some anomalies of the face andextremities. We concluded that 2D US remains the gold standardin assessment of fetal anomalies, and 3D US, therefore, is not ascreening technique but an adjunct to 2D US for those fetuses inwhom malformations are already determined or suspected onthe basis of standard sonography.