There’s an increasing interest in the use of natural products in topical skin care regimens. Vitamins are natural products with many beneficial effects on the skin. They maybe used as prescription drugs in the treatment of skin diseases and are also incorporated into cosmeceuticals, which are products with active substances that cannot be considered cosmetics or drugs. The most important vitamins in topical formulations are vitamin A, B3, B5, B12, C, D, E and K. The effect of topical vitamins used individually as well as in combinations in the treatment of various skin conditions and in cosmetic dermatology will be highlighted.