Acute kidney injury (AKI) is a major clinical problem with a rising incidence and high mortality rate. Since creatinine detects injury after more than 50% of renal function be lost & serum creatinine does not accurately depict kidney function until a steady state has been reached. So, lipocalin present an early detector of kidney function & predict outcome of kidney state. Our results showed statistically significant differences of mean lipocalin levels in the studied groups. From these results, it was concluded that serum and urinary lipocalin can be accepted as diagnostic predictors of the degree acute kidney injury as an ELISA test for the injury