Substance dependence has been recognized in-Adolescent as a major health problem and this study focusedon investigating the types of psychosocial and clinicalvariable that coexist with drug dependence in this age, alsoassessed the impact of co-morbidity on the severity ofsubstance dependence, then assessing the effect of stress andtypes o coping style of the patients then the effect ofsubstance dependence on self esteem.