Patients and methods: This study was conducted on 40 patients having hepatocellular carcinoma. They were divided randomly into two groups, each having 20 patients: 1. The first group (RFA+S group) consisted of 20 males and was subjected to radiofrequency ablation preceeded by intra-tumoral saline injection in the same setting. ( S = saline )2. The second group (RFA group) consisted of 19 males and one female and the group was subjected to ordinary radiofrequency ablation. Results: The procedure was successful in all patients (100%) of the RFA+S group and in 11 (55%) of RFA group. The remaining nine (45%) patients of RFA group shifted to PEI. This difference between both procedures was statistically highly significant. (P = < 0.01)Conclusions: RFA+S is more effective than RFA alone and as saline is cheap and available, and the intra-tumoral injection of it is easy to perform, the dramatic improvement of therapeutic effect of RFA to 100% could be a breakthrough in the future strategies to modernize the RFA technique.