Background, Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and To study the pattern of peripheral arterial disease in Egyptian patients with chronic lower limb ischaemia, overcome the lack of data resources in this field and locality. Purpose, This work studied 1717 lower limbs in 1022 patients for mapping the pattern of PAD by duplex scanning to evaluate the relationship between atherosclerotic risk factors (older age, male gender, smoking, hypertension, and diabetes mellitus) and the extent of PAD in this locality. Methodology, It started with taking the history of risk factors and cardiovascular diseases, measuring the ABI and examination of aorta and the affected lower limb by duplex ultrasonography and registering the segmental lesions (stenosis, occlusion, calcification, and/or aneurysms). Results, significant PAD is more common in older ages, male gender, smokers, hypertensive, and diabetic than control patients. Most claudicants were males and smokers (P <0.001), while most females were complaining of CLI symptoms (<0.001). CLI occurs mostly at higher ages (<0.001). Most diabetics complains of CLI symptoms (<0.001). In claudicants, SFA is the most affected segment by significant lesions (<0.001). Infra-popliteal significant lesions are common in diabetics, females, and CLI (<0.001 each), while males and claudicants are common in proximal segments (<0.001 each). Calcification increases towards the periphery and is common in females and diabetics (<0.001 each). The most affected segment of stenosis and occlusion is femoro-popliteal then infra-popliteal and the least affected segment is aorto-iliac. Conclusion, male gender, older age, smoking, diabetes mellitus, and hypertension are important risk factors of PAD in Egypt. SFA and infra-popliteal arteries were the most affected segments with significant lesions. Specific symptoms express any significant lesion at any segment. Claudication expresses proximal, while CLI symptoms express distal significant lesions. Proximal segments were affected by significant lesions mainly in males, while distal segments were affected mainly in females. Hypertension was associated with significant lesions in distal segments. DM was associated with significant lesions in infra-popliteal arteries. Smoking was associated with significant lesions in all segments except Pop A.