Breast cancer is the most important cancer among females, representing 37.5% of female cancers in the National Cancer Institute, Egypt. This study was conducted at the NCI, Cairo University. It included two parts: part 1: Cross-sectional part, to highlight detailed risk factors of breast cancer, it was conducted at the outpatient unit on 126 patients. Part 2: A total 400 breast cancer cases were randomly& proportionally selected from records of 1990, 1995 and 2000n (100 cases records from 1990, 115 from 1995 and 185 from year 2000), to detect any epidemiologic, pathologic changes and estimate survival changes and its predictors, along years 1990 to 2000. It was conducted in the biostatistics and cancer epidemiology department from May 2003 to December 2005. There were significant changes in epidemiologic factors: There is increase in the proportion of premenopausal patients, patients had early menarche and late postmenopause, higher proportion of patients had positive 1st degree family history of breast cancer. After 10 years from 1990, patients present at an earlier stage reflected in T stage, number of positive lymph node. large proportions of patients were given post operative hormonal therapy and underwent conservative mastectomy. Better DFS and OS in group 1995, 2000 than 1990.The significant independent prognostic factors were LN positivity, type of surgery, hormonal treatment, and menopausal status and year of diagnosis. T stage, pathologic grade were significant prognostic factors but not independent